Based on the above findings and previous application of the same dose (3 μg/day; 1-month infusion) in the mouse model of ALS (De Lorenzo, doctoral thesis ISSN 2342-317X), we chose here to use a dose of 3 μg per day of recombinant human CDNF (rhCDNF) for our experiments. The gene discussed is CDNF; the disease is amyotrophic lateral sclerosis.