In the 6-OHDA rat model of PD, chronic CDNF infusion (3 μg/day; 3 continuous days) improved motor imbalance and protected DA neurons37.﻿ In the TDP-43 trangenic rat model of ALS, chronic 4-week CDNF intracerebroventricular infusion (6 μg/24 h) had a positive effect on motor coordination and protected motoneurons in spinal cord24. This evidence concerns the gene TARDBP and Parkinson disease.