Next-generation sequencing for mutation screening of additional genes, such as PRKCSH, GANAB, ALG8, ALG9, SEC61B, SEC63, DNAJB11, and HNF1B, which may be associated with mild or atypical polycystic kidney disease, may allow for further elucidation of the genetic causes of atypical polycystic kidney disease by imaging14. The gene discussed is PRKCSH; the disease is polycystic kidney disease.