Next-generation sequencing for mutation screening of additional genes, such as PRKCSH, GANAB, ALG8, ALG9, SEC61B, SEC63, DNAJB11, and HNF1B, which may be associated with mild or atypical polycystic kidney disease, may allow for further elucidation of the genetic causes of atypical polycystic kidney disease by imaging14. This evidence concerns the gene HNF1B and polycystic kidney disease.