Based on the correlation patterns between immune cell infiltration and HLA and B2M expression, we found that HLA expression showed a significant positive association between HLA and B2M gene expression and the total immune infiltration, CD8 T cells, Cytotoxic cells, and T cells which indicating high HLA gene expression is related with a relatively hot tumor microenvironment (Supplementary Fig. 11g). Here, B2M is linked to neoplasm.