Our implication and exploration of ALG6 as a potential candidate gene for kidney and liver cysts results in a plausible candidate gene, supported by co-occurrence of the ALG6 loss of function variants and polycystic liver and kidney disease in several patients with supportive familial segregation of affected patients in two families, and by the statistically significant enrichment of the truncating ALG6 c.257 + 5 G > A variant in a phenotypically defined cohort of unsolved ADPKD/PCLD cases. The gene discussed is ALG6; the disease is Hepatic cysts.