The best performing diagnostic model was a 10-marker panel combining SPRR1B, CRNN, CALML3, TXN, FABP5, C1RL, MMP9, ECM1, S100A7 and CF1 and predicted endometrial cancer with an AUC of 0.92, sensitivity of 83.7% and specificity of 83.9%. This evidence concerns the gene ECM1 and endometrial cancer.