MME and chronic kidney disease: Last, to translate our findings to human disease, we sub-clustered MPC from our previously published scRNA-seq dataset of CD10 depleted (proximal tubule marker) cells isolated from seven healthy human kidneys (estimated glomerular filtration rate [eGFR] > 60 mL/min) and six kidneys with chronic kidney disease (CKD) due to hypertensive nephrosclerosis (eGFR <60 mL/min)5 (Figure S7A).