In this present study, a total 197 DEGs were identified in between Metastasis group and Non-metastasis of osteosarcoma, including downregulated genes (TP53, TPTEP1, IGJ, DDX43, NUDT10, HOXC12, et al.)and up-regulated genes (ACTA1, MYBPC1, NRAP, NEB, TNNC2, FOSB, et al.). This evidence concerns the gene TP53 and osteosarcoma.