The results demonstrated that UC-MSC secretome and CBS are able to significantly decrease cell viability, cell proliferation, inhibit the migratory behavior and decrease PI3K/AKT activation of both cancer cell lines (LNCaP and PC3), even though 25% and 50% of UC-MSC secretome seemed to enhance the viability of the LNCaP cell line, which can derive from the secretome richness in metabolites and favorable factors (such as growth factors) that can activate proliferation pathways in this particular cell lines, overwhelming the anti-tumoral effects. Here, AKT1 is linked to cancer.