For example, the pseudouridylation status at site 28S-Psi5001 was significantly higher in HEK293T FUS KO and neuroblastoma FUS KO proliferating cells, while pseudouridylation status at site 28S-Psi2839 was increased in HEK293T FUS KO and neuroblastoma FUS KO and FUS R495X differentiated cells. The gene discussed is FUS; the disease is neuroblastoma.