FUS and amyotrophic lateral sclerosis: It also proposes that ALS-associated FUS mutations might lead to increased 2’-O-Me and pseudouridylation of 18S and 28S rRNAs at specific sites, which may result in decreased translational fidelity or reduced translation of a specific set of mRNAs as observed in latest studies with particular snoRNA knockout or decrease in the steady state level of snoRNAs by introducing mutations in the biogenesis machinery25,31,32.