Our initial rationale to study the role of Mboat7 outside of the liver came from studies where we used a systems genetics approach to examine tissue-specific links between Mboat7 expression and adiposity in mice represented in the HMDP when challenged with an obesity-promoting HFD and high sucrose diet (35, 36). This evidence concerns the gene MBOAT7 and obesity due to melanocortin 4 receptor deficiency.