Interestingly, our studies show drastic effects on systemic glucose tolerance and insulin resistance in HFD fed Mboat7ASKO mice yet our euglycemic-hyperinsulinemic studies indicate no change in suppression of hepatic glucose production by insulin and only modest decreases in insulin-stimulated glucose uptake by white adipose depots (Fig. 3 and supplemental Fig. S5). The gene discussed is INS; the disease is Insulin resistance.