Although the odds ratio for the susceptible alleles is not high (at most 1.18) [1–3], these evolutional and functional underpinnings of the locus collectively suggest that an animal mimicking a decreased, but not completely nullified, activity of both FADS1/2 can be a valid model and contribute to a better understanding of the pathogenesis of BD. This evidence concerns the gene FADS1 and Behcet disease.