L1TD1 and obesity due to melanocortin 4 receptor deficiency: The only report, to date, linking L1TD1 and obesity is a study that examined genome-wide DNA methylation patterns in preadipocytes isolated from lean individuals and individuals with obesity and T2D, they observed differential methylation at L1TD1 promoter (↑ methylation in lean group) and a 2-fold increase in L1TD1 expression for the group with obesity and T2D [36].