Based on TCGA RNA-Seq and survival information available for 33 cancers, it is noteworthy that the association of high EPHA1 expression with poor survival was restricted to PCa, whereas high EPHA8 expression and poor survival was more broadly applicable to breast cancer, esophageal cancer, renal clear cell carcinoma and melanoma (Supplementary Fig. S6A). This evidence concerns the gene EPHA8 and melanoma.