Moreover, five writers (NOP2, NSUN2, NSUN3, NSUN4 and NSUN5), one reader (ALYREF) and two erasers (TET2 and TET3) were consistently upregulated in UCB tumor tissues compared to adjacent normal tissues from TCGA cohort (fold change > 1.1, P-value <0.05, occurrence rate > 50%) (Fig. 1B). The gene discussed is TET2; the disease is neoplasm.