Moreover, five writers (NOP2, NSUN2, NSUN3, NSUN4 and NSUN5), one reader (ALYREF) and two erasers (TET2 and TET3) were consistently upregulated in UCB tumor tissues compared to adjacent normal tissues from TCGA cohort (fold change > 1.1, P-value <0.05, occurrence rate > 50%) (Fig. 1B). This evidence concerns the gene NSUN4 and neoplasm.