Functional enrichment analysis using Kyoto Encyclopedia of Genes and Genomes (KEGG) indicated that regulated mRNAs by ALYREF are chiefly enriched in canonical cancer-related pathways (Fig. S4A), including TGF-β signaling, MAPK signaling, and NF-κB signaling, strongly supporting the oncogenic function of ALYREF in tumor progression. This evidence concerns the gene NFKB1 and neoplasm.