Herein, we spotted CD58, a nonclassical monocyte, such as CD274 (PD-L1) known inhibitor of T-cell activation along with Arginase 1 (Bronte et al, 2003; Li et al, 2018) highly expressed in neutrophils in COVID-19 patients or CD24 involved in neutrophil degranulation with an increased expression of neutrophil function (Overmyer et al, 2021). Here, CD58 is linked to COVID-19.