Myeloid cells can be divided in to three subtypes in CRC tissues, including monocyte/dentritic cells (Mono/DC) defined by CLEC10A, S100A8, and S100A9 expression, FOLR2+ macrophages (Macro-FOLR2), and SPP1+ macrophages (Macro-SPP1) (Fig. 4d, Supplementary Fig. 5b, c). This evidence concerns the gene SPP1 and colorectal carcinoma.