Compared with malignant and non-malignant regions, Macro-SPP1 was significantly enriched in the tumor boundary, while Macro-FOLR2 tended to be enriched in non-malignant region and Mono/DC cells tended to be enriched in the region surrounding the TLS (Fig. 4e–g, Supplementary Fig. 5d, e). This evidence concerns the gene SPP1 and neoplasm.