SFRP2 and neoplasm: For the function roles of fibroblast subtypes Fib-APSN and Fib-SFRP2, we found that Fib-ASPN, which tends to localize along the tumor boundary, is highly active in pathways that contribute to the formation of desmoplastic structures, including extracellular matrix assembly, collagen fibril organization, and collagen biosynthetic process (Supplementary Fig. 6c), while Fib-SFRP2 localized in the non-malignant region functionally enriched in collagen degradation and mesenchyme migration.