TIMD4 and lung cancer: Similar to the effect of inhibitor LY294002, TIM-4 promoted mitochondrial function and activity of lung cancer cells were reduced, including OCR (Fig. S3B, C), mitochondrial membrane potential (Fig. S3D, E), proportions of depolarized mitochondria (Fig. S3F, G), and numbers of healthy mitochondria (Fig. S3H, I).