MSH6 and neoplasm: The ASCO [27] guideline “Germline and Somatic tumor Testing in Epithelial Ovarian Cancer” recommends all women diagnosed with EOC, regardless of family history, undergo germline testing with a panel that includes BRCA1/2 and RAD51C, RAD51D, BRIP1, MLH1, MSH2, MSH6, PMS2, and PALB2. If germline testing is negative, the expert panel recommends proceeding to somatic tumour testing for BRCA1/2.