Clustering analysis of references to explore the research direction reveals that most of the references revolve around pathological essence (“transthyretin” and “amyloid protein”), disease typing (“al amyloidosis”, “familial amyloidotic polyneuropathy”, and “senile systemic amyloidosis”), treatment (“bortezomib”, “tafamidis stem cell transplantation”, and “high-dose chemotherapy”) (Fig. 8A). Here, TTR is linked to amyloidosis.