SETBP1 and Intellectual disability: SETBP1 haploinsufficiency due to heterozygous gene deletion or loss-of-function mutation causes SETBP1 disorder, a rare disorder with clinical features including expressive language impairment, intellectual disability, autistic-like traits, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), seizures, delayed motor skills and minor dysmorphic features amongst others [8–14].