Mean DNA methylation levels over − 164, − 145, − 142, and − 134 CpG sites of the p62 gene were decreased in SDB patient with nocturia versus those without nocturia (2.74 ± 0.33 versus 3.05 ± 0.91%, adjusted p = 0.042, Fig. 3H). This evidence concerns the gene SQSTM1 and sleep apnea syndrome.