Subgroup analysis showed that LC3B protein expression of blood CD3+CD4+ T helper cell was further decreased in sleep-disordered breathing (SDB) patients with depression as compared with that in those without depression (1.18 ± 0.43 versus 1.43 ± 0.48, adjusted p = 0.01, Fig. 1F). The gene discussed is MAP1LC3B; the disease is depressive disorder.