We hypothesized that protein/gene expressions of the ATG5 (marker of autophagosome formation), LC3B (marker of autophagosome and lysosome fusion), and sequestosome 1 (SQSTM1 or p62, marker of autolysosome degradation), as well as DNA methylation levels of their gene promoter regions may be different in blood leukocytes from OSA patients and primary snoring (PS) subjects. The gene discussed is ATG5; the disease is obstructive sleep apnea syndrome.