To our surprise, the results of scRNA-seq data of human hearts were consistent with those of mice, several subpopulations of fibroblasts such as fibroblast-THBS4, fibroblast-CD248, fibroblast-PDGFRA, fibroblast-DDR2 and fibroblast-POSTN were also found in human heart with heart failure. The gene discussed is PDGFRA; the disease is heart failure.