Soluble low-density lipoprotein receptor-related protein 1 (sLRP1) has been recently postulated to be a predictive biomarker for coronary artery disease (CAD) risk in a case-cohort study based on the follow-up of the REGICOR population-based cohort, in which no participants had a previous history of cardiovascular disease [11]. Here, LRP1 is linked to coronary artery disorder.