Recent reports show that circulating concentrations of fractalkine (FKN), soluble vascular cell adhesion molecule 1 (sVCAM-1), and soluble intercellular cell adhesion molecule 1 (sICAM-1) are associated positively with higher degrees of plaque inflammation; in particular, sICAM-1 predicts with high sensitivity the risk of finding highly inflamed carotid plaques and the risk of stroke recurrence within one year [10]. This evidence concerns the gene CX3CL1 and stroke disorder.