Furthermore, we designed specific primers for each TREM2 isoform (Fig. 1B and Additional file 1: Fig. S1B) and observed a significant increase of these TREM2 transcripts in post-mortem brain tissue (middle frontal gyrus) of a small cohort of control and AD patients by qPCR (Fig. 1C). Here, TREM2 is linked to Alzheimer disease.