Studies in a mouse model of myeloproliferative neoplasms such as chronic myeloid leukemia (CML) revealed that malignant cells transform osteoblast lineage cells (maybe including CAR/LepR+ cells) into inflammatory myelofibrotic cells, supporting malignant cells at the expense of normal hematopoiesis [64]. Here, LEPR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.