RP-182 peptide activates phagocytosis and autophagy in M2-like macrophages via the mannose receptor CD206, reverting these cells into an antitumor M1-like phenotype with increased M1 cytokine production, as well as the ability to phagocytose cancer cells and to aid tumor antigen recognition of intratumoral CD8 + T cells. Here, CD8A is linked to cancer.