Further, the expression of FRA1 and FLI1 significantly correlates in bladder cancer cell lines (ρ = 0.58, p-value = 1.723e-3), collectively suggesting for the co-expression status of these two transcription factors and regulation of FLI1 expression by FLI1 itself and FRA1 (Supplementary Fig. 7c). This evidence concerns the gene FOSL1 and urinary bladder cancer.