MAP4K4 is regarded one of the targets for several cancers65, also considering that many MAP4K4 inhibitors are available, which are shown to be effective for survival of cardiomyocytes86, prevention of thrombosis87 and reduction of the invasion capacity of glioblastoma88 and medulloblastoma68, targeting MAP4K4 in bladder cancer might be a valuable strategy as well. This evidence concerns the gene MAP4K4 and urinary bladder cancer.