They were associated to different cancer predisposition syndromes and all of them had an autosomal-dominant inheritance: rhabdoid tumor predisposition syndrome (SMARCA4 and SMARCB1 genes), neurofibromatosis (NF1, NF2), familial melanoma (CDKN2A), hereditary retinoblastoma (RB1) and LFS (TP53). The gene discussed is RB1; the disease is Li-Fraumeni syndrome.