carried out in silico structure homology modeling, protein-protein docking, and molecular dynamics simulation of the ability of SARS-CoV-2 S protein to bind ACE2 and found that relatively high species (monkeys, hamsters, dogs, ferrets, and cats) have an implicit effect on SARS-CoV-2 infection, supporting the association between binding affinity and infection susceptibility (Piplani et al., 2021). The gene discussed is ACE2; the disease is infection.