METRNL and coronary artery disorder: Levels of the proinflammatory adipokines TNF-α, CTRP1, salusin-β, SFRP-4, and YKL-40 were significantly higher in the CAD group relative to the NCAD group (all P < 0.05), whereas levels of anti-inflammatory adipokines, including ADP, CTRP9, salusin-α, and Metrnl, were lower in the CAD group relative to the NCAD group (all P < 0.05) (Fig. 1).