In the CAD group, we observed increased neovascularization which may be a useful pathological founding.LYVE-1 is the main receptor of hyaluronic acid in the endothelium of lymphatic vessels33, and PDPN is expressed in lymphatic endothelial cells and fibroblastic reticular cells in lymph nodes and capable of promoting lymphangiogenesis and lymphatic invasion33,34. The gene discussed is LYVE1; the disease is coronary artery disorder.