ANG and neoplasm: It is also modified with angiopep-2 (Ang), a polypeptide that can specifically target brain endothelial cells and GBM cells at the BBB site, and then load triphenylphosphine Lonidamine (obtained by modifying Lonidamine (LND) with mitochondrial targeting group triphenylphosphine (TPP), which can destroy tumor metabolism symbiosis, denoted as TLND).