Based on the overexpression of LRP on the surface of cerebral capillary endothelial cells38, we modified the nanomotors with Ang to help it break through BBB and transport effectively, so that it can play a synergistic role with the chemotaxis of nanomotors to highly expressed ROS/iNOS, thus achieving the accurate targeting of GBM. The gene discussed is ANG; the disease is glioblastoma.