NOS2 and cancer: We subsequently demonstrated that the raw material of the nanomotor has good biocompatibility (Supplementary Fig. 40a), and the PAMSe nanomotor has no significant effect on cell viability in the environment of HUVECs with low ROS/iNOS concentration (Supplementary Fig. 40b), while in cancer cells that can continuously produce ROS/iNOS cell environment, the cellular activity of the material decreased to 49.7% after incubation with cancer cells for 48 h (Supplementary Fig. 40c).