The good chemotactic ability of this kind of nanomotors on tumor cells with high expression of ROS/iNOS are confirmed by both static Y-channel model (chemotactic velocity of 6.7 μm s−1 and a maximum chemotactic index of 0.6 at a cell density of 5 × 106 cells mL−1) and dynamic microfluidic model. This evidence concerns the gene NOS2 and neoplasm.