Thus, if the autistic-like phenotype selectively observed in Ambra1+/− females establishes that autophagy insufficiency represents a major risk factor for female autism, the demonstration that normalizing hippocampal excitability in this genotype blocks the manifestation of autistic traits at the systems and circuits levels, and concurrently restores physiological levels of ERs, opens novel perspectives for treatments specifically designed for autistic females. Here, AMBRA1 is linked to autism.