INS and Insulin resistance: Increased total body muscle mass and higher total daily dose of insulin within the CRIC group, implicating increased anabolic demands due to the relatively high proportion of the protein intake [22, 23] Data from series of studies suggest that high protein intake could have detrimental metabolic effects; acute intravenous amino acid infusion or protein ingestion reduces insulin sensitivity [24–27], and habitual high protein intake is associated with insulin resistance and increased risk of developing type 2 diabetes [28–30].