Specifically, a dimer of integrin alpha-IIb (P08514)/integrin beta-3 (P05106), which showed significant increases (> 2.0-fold) in psoriasis patient with CVD risk factors in our current study (Table 2), is known to be activated through binding of fibrinogen followed by platelet aggregation51,53. This evidence concerns the gene ITGB3 and psoriasis.