Specifically, a dimer of integrin alpha-IIb (P08514)/integrin beta-3 (P05106), which showed significant increases (> 2.0-fold) in psoriasis patient with CVD risk factors in our current study (Table 2), is known to be activated through binding of fibrinogen followed by platelet aggregation51,53. The gene discussed is ITGA2B; the disease is psoriasis.