Partial deletion and deficiency of MAGUIN/CNKSR2 and point mutations in MAGUIN/CNKSR2 are involved in nonsyndromic X-linked intellectual disability accompanied with epilepsy and aphasia (17, 18, 20, 39) and MAGUIN/CNKSR2 is associated with schizophrenia (40). The gene discussed is CNKSR2; the disease is Aphasia.