The HS-RDTs enable point-of-care testing with an analytical sensitivity (limit of detection (LOD)) that is ten-fold lower than that reported for current best-in-class co-RDTs, at 80 pg of HRP2 per mL of blood [14] compared to 800-1000 pg for co-RDTs [15] as tested in vitro in malaria-negative blood. Here, HDGFL2 is linked to malaria.