The current study investigates the diagnostic utility of aberrant DNA methylation of A Disintegrin-like Metalloproteinase with Thrombospondin type 1 motif 1 (ADAMTS1), Basonuclein 1 (BNC1), and T-type calcium channel (CACNA1G) genes in differentiating histologically defined IPMN-related advanced neoplasia from IPMN-LGDs. This evidence concerns the gene BNC1 and pancreatic intraductal papillary-mucinous neoplasm.