We observed that the promoter hypermethylation of CACNA1G, ADAMTS1, and BNC1 genes had overall diagnostic accuracy, i.e., AUCs of 0.63 (0.50–0.74), 0.73 (0.61–0.83), and 0.81 (0.070–0.90), respectively, in distinguishing IPMN-related advanced neoplasia from IPMN-LGD (Fig. 2A; Table 2). The gene discussed is ADAMTS1; the disease is pancreatic intraductal papillary-mucinous neoplasm.