In addition, an experimental investigation by Yuankey et al. disclosed that ADAM metallopeptidase domain 10 (ADAM10) promotes osteosarcoma cell proliferation, migration, and invasion by regulating E-cadherin/β-catenin signaling pathway and miR-122-5p can target ADAM10, indicating that miR-122-5p/ADAM10 axis might serve as a therapeutic target of osteosarcoma [64]. This evidence concerns the gene CDH1 and osteosarcoma.