Studies have found that in healthy joints and osteoarthritis joints, the concentration of active TGFβ varies greatly; the concentration of active TGFβ in healthy joints is low, while the concentration of active TGFβ in osteoarthritis joints is higher, resulting in the activation of different signaling pathways in joint cells, and high levels of TGFβ will destroy the homeostasis of cartilage and impair the metabolic activity of chondrocytes [19, 20]. This evidence concerns the gene TGFB1 and osteoarthritis.