Upregulation and activation of P2RX7 exhibit a pro-tumoral effect in various malignant tumors, such as leukemia [18], lung cancer [19], breast cancer [20], skin cancer [21], neuroblastoma [22], pancreatic ductal adenocarcinoma [23] and esophageal squamous cell carcinoma [24]. This evidence concerns the gene P2RX7 and cancer.