Even the down-regulation of miR-21-5p can inhibit cell proliferation, induce apoptosis and cause G1 cell cycle arrest, through the reduction of AKT, CCND1 and BCL2 [33], while miR-224-5p is another miRNA that can target BCL2, as well as other genes (including RAC1, RAB10, AKT3 and p-ERK/ERK signalling), to regulate the growth of AML cells [34]. This evidence concerns the gene BCL2 and acute myeloid leukemia.