In contrast to DC-SIGN, the closely related MCL to dectin-2 has a significant synergetic effect on dectin-2 channel capacity at particularly low-stimulant concentrations, potentially making double positive cells more discriminative, at earlier timepoints of infection compared to dectin-2 expressing cells, substantiating the importance of signal integration to understand an cellular innate immune response (Ostrop and Lang, 2017). This evidence concerns the gene CLEC6A and infection.