NR1H4 and Wilson disease: Additionally, 44 hepatic metabolites (e.g., leucine, urea, ribitol, palmitic acid, oxalic acid, myo-inositol, succinic acid, ethanolamine, uracil, sorbitol, galactitol, and taurine) were commonly altered by WD, aging, and FXR deactivation (Fig. S20).