In this study, after searching the Web of Science, PubMed, and Scopus English databases from 1980 to 2022, we extracted the most related English articles with these keywords: garlic, garlic extract, aged garlic extract, allium sativum, allyl compounds, DADS, diabetes, DM, type 2 diabetes, glucose parameters, anti-glycation, hypoglycaemic, insulin-resistance, DR, BDNF, neurogenesis, neuronal survival, VEGF, VEGF-related factor, and angiogenesis factor. The gene discussed is BDNF; the disease is diabetes mellitus.