Diosgenin was found to reduce heat shock homologs in Aβ-induced injury in 5XFAD mice69, HSC70 belongs to the family of heat shock proteins and can promote neuronal axonal degeneration and pathology in the brain of AD patients when expressed at high levels70, Τhus, effectively inhibiting HSC70 as a new target for the treatment of AD (Figure 11). This evidence concerns the gene HSPA8 and Alzheimer disease.