Similarly, TRP vanilloid-1 (TRPV1), a calcium ion channel protein on the cell membrane, serving to non-selectively permeate calcium ion from the extracellular region to the cytoplasm and also was found to localize in glioma cells cytoplasm to activate mitochondrial-dependent apoptosis of glioma cells [47]. This evidence concerns the gene TRPV1 and glioma.