MKI67 and neoplasm: Furthermore, we examined the expression of Ki-67 in the xenograft tumors by IHC which demonstrated that Ki-67 positive rate was higher (*P < 0.05) in the AQP1 overexpression tumor (34.25% ± 14.23%) compared with the control tumor (48.08% ± 11.30%) as shown in the Supplementary Fig. 1f.