Especially, although current GO/KEGG results shall provide an inspiring direction for next step revealing the detailed cellular function of STC2 gene in osteosarcoma development, detailed cell lines as well as animal models experiments are needed, more importantly, the STC2 surrounding genes are on the way to be analyzed in succession for exploring the potential responsible partner genes for STC2 specific location in osteosarcoma. The gene discussed is STC2; the disease is osteosarcoma.