STC2 and osteosarcoma: Given above cNLS-mapper, TMHMM and Human Protein Atlas database predicting result which revealed that no nuclear localization regions nor transmembrane domains exist in STC2 protein structure, it is reasonable to infer that STC2 locates in octeosarcoma cellular nuclear through interacting with other elements, for instance nuclear locating transcription factors or regulators indicating a specific regulatory role of STC2 in osteosarcoma development.