Secondly, the association between STC2 expression and osteosarcoma clinical parameters was explored which result revealed that STC2 tends to expresses higher in patients with high Ki67 value and combined with tumor recurrence indicating it’s a potential disease risk indicator, meanwhile, no significance relationship was found between STC2 expression and patients age, gender, bone location, tumor volume nor necrosis (Table 1). Here, STC2 is linked to osteosarcoma.