FBXW5 and intracerebral hemorrhage: Other NIHSS-time-associated hub genes (positive correlation) included the following: SELPLG, high affinity receptor for cell adhesion molecules in leukocytes [98]; GNAI3, associated with the response to intracerebral hemorrhage [99] and involved in VEGF-induced angiogenesis [100]; and FBW5, an E3 ubiquitin ligase and negative regulator of MAP 3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway [101].