Given the link between LTCCs and neuropsychiatric disorders [2,22,23,34] and the impact of CACNA1C and CACNA1D mutations on channel function (as in Timothy syndrome [6,8,12] and ASD [24], respectively) and of CACAN1C SNPs on gene expression, it is critical to understand the contribution of LTCCs in cerebral cortex development. The gene discussed is CACNA1C; the disease is Timothy syndrome.