Notably, a similar sex difference has also been observed in Trem2 KO mice crossed with APP1/PS1 mice ([51]; females have more plaques) and human TREM2R47H cDNA mice crossed to the PS19 tauopathy model (females have more inflammatory gene expression and spatial memory deficits), as well as transcriptomic analysis of R47H-carrying AD patients ([18]; females upregulating immune activation pathways while males upregulate metabolic and adenosine triphosphate pathway). This evidence concerns the gene TREM2 and Alzheimer disease.